100% of Public Donations Fund Research.
We fund research that has the potential of curing childhood cancers today.
No More Kids with Cancer (including The Naya Foundation and Team Naya) directs 100% of donations to groundbreaking pediatric cancer research. We have been able to to accomplish the following due to the generosity of our donors:
Sequencing tumors to aid in research and discovery of better treatments.
No More Kids with Cancer has supported sequencing of pediatric brain cancer and medulloblastoma specimens in the biorepository tissue bank for use by researchers and member institutions of the CBTTC.
Partial sequencing of targeted areas of supratentorial PNET's, a heterogeneous group of aggressive brain tumors for which we have limited understanding of the tumor biology. This preliminary work was crucial prior to full genomic sequencing of the supratentorial PNET specimens in the CBTTC tissue bank, an effort which is being led by an investigator at Seattle Children's Hospital.
Research to find drugs that can halt the growth of pediatric malignant brain tumors
Dr. Kristina Cole, at the Children’s Hospital of Philadelphia, is receiving support from No More Kids with Cancer for her laboratory work studying the effect of mutations that cause ALT in pediatric malignant gliomas and embryonal tumors to determine the genes and proteins that are involved and to find drugs that can selectively halt the growth of these cancers.
One of the ways in which normal cells receive a signal that they should no longer divide is through shortening of DNA sequences at the tips of their chromosomes (telomeres) with each cellular division. Some cancers, including subsets of pediatric malignant gliomas and pediatric embryonal tumors have developed mutations that keep their telomeres extra long (alternative lengthening of telomeres, or ALT) and give these cancer cells a growth advantage.
Clinical trials lead to better and safer treatments, and more cures.
$155,000 award to UCSF’s Pacific Pediatric Neuro-Oncology Consortium (PNOC) to support a Phase 1 clinical trial to determine the effectiveness of an engineered measles virus to kill medulloblastoma – a common form of childhood brain cancer. This form of treatment seeks to use the virus to infect and destroy cancer cells while leaving normal cells intact. Sabine Mueller, M.D., Ph.D. is the principal investigator.
The trial will be made available through hospitals participating in PNOC’s consortium including the hospitals below:
- Dana Farber/Boston Children’s
- St. Louis Children’s Hospital
- Nationwide Children’s Hospital
- Ann & Robert H. Lurie Children’s Hospital of Chicago
- St. Jude Children’s Research Hospital
- Children’s National Medical Center
- The Children’s Hospital of Philadelphia
- Seattle Children’s Hospital
- Doernbecher Children’s Hospital
- Oregon Health & Science University
- University of Utah
- Children’s Hospital and Research Center Oakland
- University of California, San Francisco
- University of California, Los Angeles
- Children’s Hospital Los Angeles, University of California
- San Diego Rady Children’s Hospital
Approximately $100,000 for a clinical research associate (CRA) to expand the Neuro-oncology program at The Children’s Hospital of Philadelphia, expanding the hospital’s ability to open clinical trials.