The Mustard Challenge raises awareness and funds to discover safer, non-toxic and more effective treatments for children with cancer – the leading cause of death by disease of children in the U.S. By taking the challenge and donating, you raise awareness of the ancient drugs used to treat our kids and fund groundbreaking research for childhood cancer.

Why mustard?

Today, children are commonly treated with 1950s drugs derived from the same compounds used in mustard gas, and only 3 drugs have been approved for childhood cancer since 1980. These ancient drugs are highly toxic and cause acute side effects – even death - as children become adults.

100% of Your Donation Funds Research

All of the money raised from The Mustard Challenge will fund groundbreaking research that leverages the latest understanding in cancer biology to bring safer, less toxic and more effective treatments for children with cancer. 

Matching Donation from Stand Up To Cancer

Now, you can turn your $25 donation into $50, or your $1,000 donation into $2,000! How? The first $6 million raised by the Mustard Challenge will be matched dollar-for-dollar up to a total of $6 million by Stand Up To Cancer.



Anyone over 13 years old can take the Mustard Challenge. If you are sensitive to mustard, you can take the challenge with something else equally challenging. Have fun!

  1. PREPARE: Choose your mustard, the spicier, the better. See Bravery Level meter for levels.Be ready to record your challenge using a phone or camera with video recording capabilities.

  2. RECORD YOUR CHALLENGE:  Set up your phone/camera, and start recording.

    1. SAY “Hi, this is my mustard challenge to end childhood cancer. I'm taking the challenge and donating to raise funds for cancer research."

    2. EAT (or SMEAR, THROW, SQUIRT, ETC.) a big spoonful of mustard. We suggest you have crackers or water nearby!

    3. SAY "I challenge friends A, B, C and D to do the challenge and make a donation at mustardchallenge.com."

  3. DONATE any amount to fund childhood cancer research. Stand Up To Cancer will match your donation $1 for $1, up to a total of $6 million!

  4. SHARE and GO VIRAL: POST the video to your Facebook, Instagram, and Twitter account. Tag the people you nominated (using the @ symbol) and add the hashtag #MustardChallenge and website mustardchallenge.com to encourage donation


    Change the facts and stand up for kids

    100% of your donation helps discover safer, less toxic, and effective treatments for kids with cancer.

    How Hot can you handle?

    The bigger the heat, the braver the bite. Can you handle the eye-watering smack of Wasabi Mustard, or do you max out at yellow? Give it your best shot!   

    Our Goal: $6,000,000+

    Our goal is at least $6,000,000! Help us reach it and go over! We will change our goal if we exceed $6,000,000!



    All (100%) of the money raised from The Mustard Challenge will fund groundbreaking research that leverages the latest understanding in cancer biology to bring safer, less toxic and more effective treatments for children with cancer. The research we fund will help children with cancer — and the doctors and researchers working to save them — who urgently need alternatives to the 50s-era, inhumane, side-effect-laden standard treatments used today. 

    The First $6 Million Funds a New, Collaborative Pediatric Brain Cancer Dream Team 

    No More Kids with Cancer is collaborating with Stand Up To Cancer (SU2C) to fund a new Pediatric Brain Cancer Dream Team. No More Kids with Cancer (NMKwC) will donate to SU2C up to a total of $6 million from the contributions made through the Mustard Challenge. SU2C will match the donation dollar-for-dollar up to a total of $6 million. The combined funds from NMKwC and SU2C will be used to fund a new, collaborative Pediatric Brain Cancer Dream Team. A scientific ‘Dream Team’ is made up of researchers in multiple disciplines and institutions to bring options to children faster. Dream Teams are accelerating cures and treatments in adult cancers today and the same model can be applied to children.

    If the Mustard Challenge raises more than $6 million, amounts will be applied to additional groundbreaking research projects. Our Scientific Review Committee will seek projects and opportunities with a high potential of creating breakthroughs and safer treatments for children with cancer. We won’t fund just any project. We will seek to fund novel ideas, therapies and options that result in safer and more effective treatments. 

    We will actively seek to support high-potential early stage clinical trials (phase 0, phase I, phase II) or other clinical research (e.g. biomarker development, new imaging tools, etc.) targeting pediatric cancer. The projects can be one or a combination of the following: kick-starter grants between $100,000-$250,000; clinical trials between $250,000 - $1,000,000 or grants to early-career physician-scientists with novel ideas to cure childhood cancer averaging $100,000 - $250,000 per year; and larger grants which have the possibility to accelerate cures for a type of pediatric cancer, including another Dream Team.



    Participating in the Mustard Challenge is at your own election. If you have a sensitivity to mustard – please use something else or donate! Also, when you set your social media status to "public" and post your video, anyone on the web can see your post. When you post, you permit us to display your post on our website. Finally, if you are under 13, please do not participate in the challenge, but feel free to ask your parents to do so!



    The Mustard Challenge team consists of volunteers who came together to make a difference. We want to thank the following individuals and organizations for their time, ideas and help:

    Pure Growth team with special thanks to Oli and Dani

    Ballard Spahr with special thanks to Odia Kagan and Lynn Rzonca

    No More Kids with Cancer team - Christine Tase and Chris Blackman

    LyncServe team with special thanks to Kevin and Jillian